Sex Differences in Brain Aging

Aging: Manipulating Sex Differences

The life histories of animals are marked by two pervasive characteristics — nearly all animals reproduce sexually, and virtually all exhibit the hallmarks of physiological deterioration (i.e. senescence) with advancing age. While some animal species are hermaphroditic, many — including ourselves — are characterized by distinct sexual entities (gonochorism); individuals are either male or female...

Sex differences in the brain.

Brain size, sex, and the aging brain.

This study was conducted to examine the statistical influence of brain size on cortical, subcortical, and cerebellar compartmental volumes. This brain size influence was especially studied to delineate interactions with Sex and Age. Here, we studied 856 healthy subjects of which 533 are classified as young and 323 as old. Using an automated segmentation procedure cortical (gray and white matter...

Sex differences in brain aging: a quantitative magnetic resonance imaging study.

BACKGROUND Little is known about the effect of sex on age-related changes in brain structure. METHODS Quantitative magnetic resonance imaging of the brain was performed in 330 elderly (age range, 66-96 years) volunteers living independently in the community, all of whom were participants in the Cardiovascular Health Study. Blinded measurements of global and regional brain size were made from ...

Oversimplifying Sex Differences in the Brain